肌肉萎缩（True EPUB）

English | EPUB (True) | 2018 | 618 Pages | ISBN : 9811314349 | 29.8 MB

The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book’s fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy. The book will appeal to a broad readership including scientists, undergraduate and graduate students in medicine and cell biology.

这本书探讨了肌肉萎缩的发展，这可能是由于去神经支配、缺乏使用、过度节食、老化以及包括心力衰竭、慢性肾病和癌症在内的多种疾病所导致。肌肉萎缩降低了生活质量，并在全球范围内增加了发病率和死亡率。本书分为五部分，第一部分描述了肌肉萎缩的总体特征，包括其相关经济和社会负担，以及当前的临床疗法。第二部分总结了肌肉萎缩的基本方面，包括骨骼肌的组成、结构与功能，以及在萎缩反应中的变化，以及实验模型。第三部分回顾了肌肉萎缩的分子机制，包括蛋白质降解和合成途径、非编码RNA、炎症信号传导、氧化应激、线粒体信号传导等。第四部分强调了肌肉萎缩在老化和疾病中的病理生理机制。本书的最后一部分涵盖了肌肉萎缩的诊断策略、治疗方案、前景以及潜在药物。这本书将吸引广泛的读者群体，包括医学和细胞生物学领域的科学家、本科生和研究生。

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