阿尔茨海默病基于天然产物的合成药物分子

English | 2023 | ISBN: 9819960371 | 794 Pages | PDF EPUB (True) | 37 MB

This book illustrates the importance of natural products as the source for the development of novel drugs for the treatment of neurodegenerative disorders, including Alzheimer's disease. It also highlights the role of reactive oxygen species and altered metal homeostasis in the progression of Alzheimer’s disease and examines the potential of antioxidants and anti-chelating agents in the clinical intervention of neurodegenerative diseases. The book also discusses the role of neuroinflammation in the pathogenesis of Alzheimer’s disease. The chapters provide information about the drug targets, progress in the development of natural product-based therapeutics, biomarkers, fluorescent diagnostic tools, and theranostic for Alzheimer's disease. The book also provides information about the design and synthesis of natural product-based derivatives against the various targets of Alzheimer's disease including epigenetic targets and the metal dyshomeostasis hypothesis. Cutting across different disciplines, this book is a valuable source for neuroscientists, chemical biologists, pharmaceutical researchers, and synthetic biologists.

这本书介绍了天然产物作为开发治疗神经退行性疾病的新药来源的重要性，包括阿尔茨海默病。它还强调了活性氧和金属稳态改变在阿尔茨海默病进展中的作用，并研究了抗氧化剂和络合剂在神经退行性疾病的临床干预中的潜力。本书还讨论了阿尔茨海默病发病机制中神经炎症的角色。章节提供了有关阿尔茨海默病药物靶点、基于天然产物的治疗方法的发展进程、生物标志物、荧光诊断工具以及阿尔茨海默病的治疗与诊断（theranostic）的信息。此外，本书还介绍了针对阿尔茨海默病各种目标（包括表观遗传学目标和金属失衡假设）的天然产物衍生化合物的设计与合成信息。跨越多个学科领域，这本书对神经科学家、化学生物学家、制药研究人员以及合成生物学家来说是一个有价值的资源。

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