还原调控和癌症治疗策略

English | 2023 | ISBN: 9819973414 | 435 Pages | PDF EPUB (True) | 9 MB

This book aims to provide an association of the major redox-sensitive pathways and networks involved in cancer. The initial chapter of the book discusses basic information about oxidative stress, its generation, and regulation (redox regulation or redox homeostasis) via cell signaling in normal and cancer cells. The book also explores antioxidants and metabolic events in cancer cells compared to normal cells. It further covers the application of nanoparticles in redox regulation in cancer cells. The role of redox regulation in cancer therapy, its influence, and its involvement in programmed cell death (PCD), metastasis, immune system, p53, and cell cycle/DNA damage repair pathways have been discussed in separate chapters. It further reviews the importance of dietary phytochemicals in redox regulation in normal and cancer pathophysiology. Towards the end, the book focuses on the role of redox balance, especially in ROS-dependent cellular processes in cancer stem cells.

这本书旨在提供癌症中主要的氧化还原敏感途径和网络的关联。本书的第一章讨论了正常细胞和癌细胞中的氧化应激的基本信息，包括其产生以及通过细胞信号进行的调节（即氧化还原调节或氧化还原稳态）。此外，该书还探讨了癌细胞与正常细胞之间的抗氧化剂及其代谢事件。它进一步涵盖了纳米颗粒在癌细胞氧化还原调节中的应用。分别讨论了氧化还原调节在癌症治疗中的作用、其影响以及其在程序性细胞死亡（PCD）、转移、免疫系统、p53以及细胞周期/DNA损伤修复途径中所发挥的作用。随后，该书回顾了饮食中的植物化学物质对正常和癌症病理生理学中的氧化还原调节的重要性。最后，该书关注的是氧化还原平衡特别是与癌干细胞的ROS依赖性细胞过程中的作用。

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