感染性疾病中的中性粒细胞

English | February 16, 2018 | ISBN-10: 1608053822 | 87 pages| PDF | 13 MB

Host defense to intracellular pathogens depends upon both innate and adaptive cell-mediated immune responses. Polymorphonuclear neutrophil leukocytes which belong to the innate immune system are the first cells that are recruited massively within hours of microbial infection. The importance of neutrophils in the development of an immune response is only emerging as they have long been considered by immunologists as short lived, non-dividing cells, of poor interest. Now, neutrophils are emerging as key components of the inflammatory response, and are shown to have immunoregulatory roles in microbial infections. The impact of neutrophils on cells present at the site of infection is only beginning to be studied and deserves more attention. This book provides an overview of the recent advances made in the field of neutrophil biology and motions towards some of the exciting new directions in which neutrophil research is moving.

宿主对胞内病原体的防御依赖于先天性和适应性细胞介导的免疫反应。中性粒细胞属于先天免疫系统，它们在微生物感染数小时后会被大量招募。免疫学家长期以来一直认为中性粒细胞是短暂、无分裂且不感兴趣的细胞。现在，中性粒细胞正逐渐被认识到在炎症反应中的关键作用，并已显示出参与微生物感染的免疫调节功能。目前，我们还在逐步研究这些病原体感染现场的细胞对中性粒细胞的影响，需要给予更多的关注。本书概述了近年来在中性粒生物学和研究方向方面取得的最新进展。

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