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慢性疼痛:新的分子洞察痛感及其治疗

English | 2023 | ISBN: 9814324523 | 341 pages | True PDF | 38.86 MB

This book successfully explores cellular and molecular mechanisms of chronic pain based on recent basic neurobiological investigations. By focusing on major breakthroughs in basic neurosciences, it is believed to contain the promise for future new pain drug discovery.Instead of repeating extensive reviews of basic animal and clinical observations, the book provides a novel neuronal model that is believed to be the key target for treating chronic pain. In addition, it reviews and validates animal models developed for studying basic mechanisms of pain and chronic pain, and the current medicine used to treat chronic pain as well as alternative pain treatment. The final few chapters also cover how pain may interfere with other high brain functions, such as fear, anxiety, sleep, memory, etc.


这本书成功地基于最近的神经生物学基础研究,探讨了慢性疼痛的细胞和分子机制。通过专注于基本神经科学领域的重大突破,被认为包含未来新止痛药物发现的希望。不同于重复大量的动物和临床观察的详细综述,该书提供了一个被认为是治疗慢性疼痛的关键靶点的新神经元模型。此外,它还回顾并验证了用于研究疼痛及其慢性疼痛基本机制的动物模型以及目前用来治疗慢性疼痛的现有药物,以及替代的止痛方法。最后几章也涵盖了疼痛可能如何干扰其他高级脑功能,如恐惧、焦虑、睡眠、记忆等。
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