胆固醇结晶在动脉粥样硬化和其他相关疾病中的作用

English | 2023 | ISBN-10: 3031411919 | 519 pages| PDF (True) | 31 MB

This book is the first authoritative and comprehensive text dedicated to the understanding of how cholesterol triggers vascular inflammation and mechanical injury that leads to heart attacks, strokes as well as other organ and tissue pathology. It includes chapters on the background of cholesterol crystal formation and methods for their detection as well as a description of the physiochemical transformation of metastable ‘liquid’ cholesterol to a solid flat plate crystalloid within the cellular and extracellular environment resulting in volume expansion. Chapters also discusses cholesterol crystals and other crystalloid molecules found in atherosclerotic plaque. In addition, the book examines how cholesterol crystals can induce similar injurious processes in other organs including the retina of the eye to cause blindness, in solid cancers causing further tumor growth and in the brain of patients with Alzheimer’s. And lastly, the book addresses various potential therapeutics that disrupt the physiochemical transformation of cholesterol from a liquid to a solid, inhibit its role in triggering inflammation and tissue injury while ushering a path towards targeted therapies.Cholesterol Crystals in Atherosclerosis and Other Related Diseases will be of interest to cardiologists as well as individuals in various fields of science including crystallography, basic and clinical imaging, cardiac oncology, and drug discovery.

这本书是第一部专注于胆固醇如何触发血管炎症和机械损伤，进而导致心脏病、中风以及其他器官和组织病变的权威性和综合性的教科书。书中包括关于胆固醇结晶形成背景章节以及检测这些结晶的方法，并描述了在细胞内环境和细胞外环境中发生于稳定“液态”胆固醇到固体扁平晶状物的物理化学变化，导致体积膨胀的过程。此外，书中还探讨了胆固醇结晶以及其他存在于动脉粥样硬化斑块中的晶状分子如何在其他器官中引发类似的损伤过程，包括视网膜以造成失明，在实体癌症中促进肿瘤生长以及阿尔茨海默病患者的大脑中引起进一步的病变。最后，本书讨论了许多可能的治疗方法来阻止胆固醇从液态变为固态的过程、抑制其触发炎症和组织损伤的作用，并为靶向治疗铺平道路。《动脉粥样硬化及其他相关疾病中的胆固醇结晶》将吸引心脏病专家以及各领域科学工作者的兴趣，包括晶体学、基础和临床成像、心脏肿瘤学和药物发现等。

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