信号通路在脑瘤发生发展中的作用

English | November 21, 2023 | ISBN-10: 9811584729 | 231 pages| PDF (True) | 7 MB

This book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours.

这本书提供了一个全面的脑瘤起源中细胞信号通路和形态发生素概述。它还解释了脑瘤干细胞在脑瘤进展中的作用。此外，它阐述了可用于诊断脑瘤的新颖早期生物标志物。本书介绍了基本的发展途径和形态发生素，包括促进脑瘤发生的视黄酸和TGF-β。章节展示干细胞及其介导的细胞信号通路的作用，如Sonic hedgehog、Notch、Wnt在脑瘤生长中的作用。章节还强调了转录因子Nanog、Sox、BMI1、HIF1和Pax6在脑瘤发生的角色。它突出了NF-kB、Myc和神经营养因子在脑瘤发展中所起的作用。最后，本书总结了潜在的早期治疗靶点和针对脑瘤的靶向药物发现的可能性。

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