靶向DNA损伤响应进行癌症治疗：蒂莫西·A·雅普（ Timothy A. Yap）

English | 2023 | ISBN-10: 3031300645 | 338 pages| Epub PDF (True) | 16 MB

This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic. Targeting the DNA Damage Response for Cancer Therapy comprehensively reviews the application of PARP and other DDR inhibitors across oncology disciplines. Therefore, it is a valuable resource for all medical professionals and researchers who use or who are researching the use of these inhibitors on a day-to-day basis.

这本书讨论了聚（ADP-核糖）聚合酶（PARP）抑制剂药物开发的最新发展。它专注于最新的药物从转化和临床开发，以及在多种不同的分子亚型和肿瘤指示方面PARP抑制剂的监管批准证据。还涵盖了关于DNA修复途径和DNA损伤反应（DDR）的基本科学研究所获得的最及时信息。每章都包含了对特定DDR抑制剂的前临床、转化以及临床方面的见解，关键专家意见点强化了最为重要的概念，使读者能够深入理解这一话题。 《针对癌症治疗靶向DNA损伤响应》全面回顾了PARP和其他DDR抑制剂在肿瘤学领域的应用。因此，它对于所有日常使用或研究这些抑制剂的医疗专业人员和研究人员来说都是一个宝贵的资源。

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