丝氨酸蛋白酶：在人类健康与疾病中的作用（True EPUB）

English | ISBN: 3111324982 | 2023 | 157 pages | EPUB | 4 MB

Serine proteases play significant roles in healh and human disease. Abnormal expression and activities of serine proteases have been linked to the pathogenesis of many diseases. The book presents correlation between serine proteases and human diseases. It helps the reader understand classification, catalytic mechanism and types of serine proteases and their role in human disease pathogenesis at mechanistic level. The chapters explain the role of serine proteases in various diseases including respiratory disorders and cancer. It also covers the therapeutic importance of serine proteases as drug target and explains the mechanistic insights of serine proteases inhibitors. Serine protease are known to play crucial role in biological processes but disturbance in their equilibrium can result in serious health conditions. To maintain homeostasis, serine protease inhibitors come in action and inhibit proteases. Several serine protease inhibitors have been identified and many more are being designed as novel compounds for inhibitions of proteases that provide management of comorbidities. Therefore, this book will serve as a useful reference for students and researchers to understand physiological role of serine proteases and their association with initiation and progression of human diseases. It will also help to develop some strategies to develop serine proteases inhibitors as drug target of serine proteases at cellular and molecular level.

丝氨酸蛋白酶在健康和人类疾病中扮演着重要的角色。异常表达和活性的丝氨酸蛋白酶与许多疾病的发病机制有关。本书介绍了丝氨酸蛋白酶与其人类疾病之间的关联。它帮助读者理解丝氨酸蛋白酶的分类、催化机制以及其在人体疾病发病机制中的类型及作用。各章节解释了丝氨酸蛋白酶在各种疾病，包括呼吸系统疾病和癌症中的作用。此外还涵盖了丝氨酸蛋白酶作为药物靶点的治疗重要性，并解释了丝氨酸蛋白酶抑制剂的机理见解。丝氨酸蛋白酶已知在生物过程中发挥着关键作用，但它们平衡的扰乱会导致严重的健康状况。为了维持稳态，丝氨酸蛋白酶抑制剂会启动并抑制这些蛋白酶。已经鉴定出几种丝氨酸蛋白酶抑制剂，并且正在设计更多作为新型化合物以抑制蛋白酶从而管理共存性疾病。因此，本书将作为学生和研究人员理解丝氨酸蛋白酶的生理作用及其与人类疾病的起始及进展之间的关联的有效参考工具。此外，它还将帮助开发一些策略来发展丝氨酸蛋白酶抑制剂作为丝氨酸蛋白酶的细胞和分子水平上的药物靶点。

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