胰腺癌：目前治疗和未来方向

English | 2023 | ISBN-10: 3031386221 | 203 pages| PDF (True) | 6 MB

Pancreatic cancer is a challenging and complex disease characterized by a dense fibrotic stroma and an immunosuppressive tumor microenvironment. Until recently, there were no predictive biomarkers to personalize selection of targeted or biologic therapies as a part of standard of care treatment. Moreover, the regulatory immune population of cells creates a “cold”, non-immunogenic tumor that is resistant to immunotherapies including checkpoint inhibitors. However, in the last few years, there has been substantial progress in our understanding of the role mutations in the pathogenesis of disease leading to increased adoption of germline and next generation sequencing to identify mutations and fusions to optimize selection of therapies and select patients for clinical trials of targeted agents.This book provides a comprehensive, global overview on therapy for pancreatic cancer, exploring approved therapies and focusing on the “Next” in drug development including molecularly targeted therapy and efforts at “Drugging the Undruggable”: the KRAS mutation. It also addresses efforts at targeting the inhospitable stroma to improve drug delivery to the tumor cells, incorporating ct DNA (liquid biopsies) in the care of patients and recent advances in immunotherapy. Pancreatic Cancer: Current Therapeutics and Future Directions will illuminate these challenges, review existing therapeutics, and highlight current and future efforts to improve outcomes in this devastating disease. Useful to physicians, fellows, medical students, residents, physician assistants, nurse practitioners, pharmaceutical companies and researchers interested in pancreatic cancer, it will first explain management of localized disease including resectability and adjuvant and neoadjuvant therapies. Targeted therapies including molecular, immunotherapy, stroma and role of ctDNA or “liquid biopsies” will be addressed. Finally, the book will explore the important role of pain management, diet and exercise in improving outcomes in pancreatic cancer.

胰腺癌是一种具有密集纤维化基质和免疫抑制性肿瘤微环境的挑战性和复杂的疾病。直到最近，治疗标准护理中个性化选择靶向或生物疗法还没有预测标志物。此外，调节性免疫细胞群的存在使得形成“冷”且非免疫性的肿瘤，该肿瘤对包括检查点抑制剂在内的免疫疗法具有抗性。然而，在过去的几年里，我们对疾病的发病机制中的突变所起的作用的理解有了显著的进步，并推动了从遗传背景和下一代测序中识别突变和融合来优化治疗选择，并将患者纳入靶向药物临床试验的采用。此书提供了胰腺癌治疗的综合全球概览，探讨了已批准的治疗方法，并关注于新药开发中的“Next”，包括分子靶向疗法以及针对“难以成药”的KRAS突变的努力。“冷”肿瘤基质的靶向努力旨在改善对肿瘤细胞的药物输送。该书还纳入了ctDNA（液体活检）在患者护理中的应用，以及近期免疫疗法的进步。 《胰腺癌：现有治疗和未来方向》将阐明这些挑战，回顾现有的治疗方法，并强调提高这种毁灭性疾病预后的当前和未来的努力。此书对希望了解胰腺癌的医生、助理医生、医学学生、住院医师、执业药剂师、护理专业人员以及关注胰腺癌的制药公司和研究人员来说都很有用。它首先会解释局部疾病管理，包括可切除性和辅助及新辅助治疗。还将探讨针对分子、免疫疗法、基质和ctDNA或“液体活检”的靶向治疗方法。最后，该书将探索疼痛管理、饮食和锻炼在改善胰腺癌预后中的重要作用。

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