康斯坦丝·佩特：科学世界中的天才、贪婪与疯狂

English | November 7th, 2023 | ISBN: 0306831465 | 304 pages | True EPUB | 0.82 MB

The story of maverick scientist Candace Pert, whose groundbreaking research and book Molecules of Emotion introduced the world to the mind-body connection, opioid receptors, and peptide T, and her fight for recognition in a toxic healthcare system.

Candace Pert stood at the dawn of three revolutions: the women’s movement, integrative health, and psychopharmacology. A scientific prodigy, she was 30 years ahead of her time, preaching a holistic, interdisciplinary approach to healthcare and medicine long before yoga hit the mainstream and “wellness” took root in our vernacular. Her bestselling book Molecules of Emotion made her the mother of the Mind/Body Revolution, launching a paradigm shift in medicine. Deepak Chopra credits her with creating his career, and he said as much in his eulogy at her funeral.

Candace began her career as an unbridled maverick. In 1972, as a 26-year-old graduate student at Johns Hopkins, she discovered the opiate receptor, revolutionizing her field and enabling pharmacologists to design new classifications of drugs from Prozac to Viagra to Percocet and OxyContin. The tragic irony of her breakthrough, touted as the first step to end heroin addiction, is that it helped spawn a virulent epidemic of drug dependence. Facing the largest public health crisis of the 21st century, Candace was incensed that the Hippocratic oath—“first, do no harm”—would succumb to greed, and as witness to this abuse of power, she was one of few scientists courageous enough to protest.

Later, as Chief of Brain Biochemistry at the National Institutes of Health, Candace created Peptide T, the non-toxic treatment for HIV featured in Dallas BuyersClub. As the AIDS pandemic raged, triggering panic across Reagan-era America, the U.S. government poured massive amounts of money into finding a cure, sparking a battle among scientists for funding and power. Bested by rivals with competing drugs yet desperate to help, Candace went rogue, becoming a lynchpin in the black market for Peptide T.

After a scandalous departure from her tenured position at the NIH, Candace launched a series of private companies with Michael Ruff, her second husband and collaborator. Naïve to the world of business, she was manipulated by investors keen to wrest control of her discoveries. But Candace too became tainted, believing that her noble ends would justify devious means. Like a mythic hero, she succumbed to a fatal flaw, and her greatest strengths—singularity of purpose and blind faith in her own virtuosity—would prove to be her undoing.

科学家奇点康斯坦丁·佩特的故事，她的开创性研究和书籍《情绪分子》将世界引入了身心连接、阿片受体以及肽T的认识，并且她在充满毒素的医疗体系中为得到认可而斗争。

佩特女士站在三场革命的起始：女性运动、整合健康及精神药物学。她是一个科学奇才，三十年之前就领先时代，在医学和医药领域提倡一种综合性的跨学科方法，这远早于瑜伽成为主流以及“ wellness”这一词扎根我们的日常用语。她的畅销书《情绪分子》使她成为了身心革命的母亲，并引发了医学领域的范式转变。

德夫卡·克普罗将她视作创造他职业生涯的人，并在她的葬礼上也表达了这种看法。

佩特女士的职业生涯以一个不受束缚的叛逆者开始。1972年，作为约翰霍普金斯大学的一名26岁研究生时，她发现了阿片受体，从而彻底改变了她所在的领域，并使药理学家能够设计出从帕罗西汀到伟哥再到扑热息痛和奥施康定等新分类的药物。她的突破之悲惨讽刺是，它被吹捧为结束海洛因成瘾的第一步，却促进了一种充满毒性的药物依赖流行病。面对21世纪最大的公共卫生危机，佩特女士愤怒地认为《希波克拉底誓言》——“首先无害”——将屈服于贪婪，而作为这场滥用权力的见证者之一，她也是少数敢于抗议的一位科学家。

后来在国家卫生研究院担任神经化学家时，佩特创造了肽T这一非毒性艾滋病治疗方法，并且与她第二任丈夫兼合作者迈克尔·鲁夫合作创立了多个私人公司。对商业世界一无所知的她被投资者操控，以夺取她的发现控制权。然而佩特女士同样也受到了污染，相信自己高尚的目标将允许她采用不道德的方法。如同一个神话英雄一样，她陷入了致命的弱点，并且她的最大优势——专注目标和对自己天赋的盲目信任——最终成为她的终结者。

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