纳米药物治疗肝细胞癌

English | 2022 | ISBN: 9815039768 | 799 Pages | PDF EPUB (True) | 27 MB

Hepatocellular carcinoma (HCC) is a leading cause of death globally. Conventional chemotherapeutic agents are unable to penetrate cancerous hepatocytes completely and are toxic to non cancerous cells and tissues. This toxicity significantly compromises the therapeutic outcome of conventional chemotherapeutic agents which is also reflected in the high mortality of the disease. Nanotherapeutics have shed new light onto HCC treatment by enabling site-specific in vivo delivery of chemotherapeutics specifically to neoplastic hepatocytes without affecting normal hepatocytes. Thus, nanotherapeutics have shown considerable potential and there is tremendous impetus for rapid translation from the pre-clinical to the clinical domain to significantly prolong the survival in HCC.

肝细胞癌（HCC）是全球致死的主要原因之一。传统化疗药物无法完全渗透到癌变的肝细胞中，并且对非癌性细胞和组织有毒性，这种毒性显著影响了传统化疗药物的疗效，这也体现在疾病的高死亡率上。纳米治疗学通过实现以特定方式将化疗药物精确递送到肿瘤性肝细胞而不影响正常肝细胞的方法，为HCC治疗带来了新的希望。因此，纳米治疗具有巨大的潜力，并且急需从临床前研究迅速转移到临床领域，从而显著延长HCC患者的生存期。

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