预测性、预防性和个性化医疗：从实验室到病床

English | 2023 | ISBN: 3031348834 | 689 Pages | PDF (True) | 11 MB

This volume presents advanced bio/medical sciences with a particular value for translating research achievements into daily medical practice in the framework of Predictive, Preventive and Personalised Medicine (3PM/PPPM). First two decades of the 21st century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. The absolute majority of expanding non-communicable disorders carry a chronic character, over a couple of years progressing from reversible suboptimal health conditions to irreversible severe pathologies and cascading collateral complications. The paradigm change from reactive to predictive preventive and personalised medicine is essential to promote population health by application of individualised patient profiling, multi-parametric analysis leading to cost-effective targeted prevention. To this end, inadequate data for risk assessment on speed and urgency of COVID-19, combined with increased globalization of human society, led to the rapid spread of COVID-19. Despite an abundance of digital methods that could be used in slowing or stopping this virus and future pandemics, the world remains unprepared, and lessons have not been learned from previous cases of pandemics. The book presents PPPM strategies which might be of great clinical utility for future pandemics.

这本书介绍了高级生物/医学科学，并且特别强调了将研究成果转化为日常医疗服务在预测性、预防性和个性化医疗（3PM/PPPM）框架中的价值。21世纪前两个十年中，非传染性疾病如心血管疾病和2型糖尿病患者数以亿计的诊断病例、乳腺癌、肺癌、肝癌和前列腺癌、神经系统疾病、睡眠障碍、情绪及视力问题等疾病的爆发尤为显著。由此造成的社会经济负担巨大。据报道，适应不良个体的平均年龄有所降低。几乎所有的扩大非传染性疾病都具有慢性性质，几年内从可逆的次优健康状况发展到不可逆的严重病理状况，并引发一系列并发症。由被动式应对向预测性、预防性和个性化医疗模式转变对于促进人口健康来说至关重要，这需要应用个体化患者评估、多参数分析以实现成本效益的针对性预防。为了达到上述目标，尽管可用于减缓或停止该病毒以及未来大流行的方法丰富多样，但世界仍未做好准备，并且没有从以往疫情案例中学到教训。本书介绍了一些可能对未来的流行病有重大临床价值的PPPM策略。

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