铁凋亡在健康与疾病中的第2版

English | 2023 | ISBN-10: 3031391705 | 498 pages| PDF (True) | 13 MB

This updated and expanded volume gives new insights on ferroptosis – an iron-dependent form of non-apoptotic cell death. The collection of chapters discusses the two major pathways through which ferroptosis can occur: the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathway. Readers will gain an understanding of the multiple levels, on which this special cell death is regulated. Hence, the contributions will take a closer look at epigenetic, transcriptional, posttranscriptional and posttranslational layers. Among the described regulators and transcription factors are GPX4, ACSL4 and NFE2L2.

This edited volume collects reviews related to current knowledge on the integrated molecular machinery of ferroptosis, thereby also describing how dysregulated ferroptosis is involved in human diseases.

更新并扩展的这一卷为铁依赖性的非凋亡细胞死亡形式——即ferroptosis——提供了新的见解。章节集合讨论了ferroptosis可以通过两种主要路径发生：外在或依赖运输蛋白的途径和内在或酶调节的途径。 读者将了解到，这种特殊类型的细胞死亡是如何受到多个层面调控的理解。因此，贡献者将更仔细地审视表观遗传学、转录性、后转录性和翻译后的层次。所描述的调节因子和转录因子包括GPX4、ACSL4和NFE2L2。 这一编辑卷收集了与ferroptosis整合分子机制相关评论，从而也描述了失衡的ferroptosis如何参与人类疾病。

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