癌症和纳米医学中的后基因组学方法

English | ISBN: 8793102860 | 2015 | 384 pages | PDF | 26 MB

Understanding the molecular mechanisms of cancer is the key for transforming cancer medicine. A substantial proportion of human genes show alternative splicing and mis-regulation of Pre-mRNA splicing is seen in several cancers.This book further investigates these matters. The first few chapters provide an update on the role of genomics in understanding alternative splicing, and targets in cancer pathogenesis. Advances and prospects in applications of nanotechnology for cancer prevention, detection and treatment are a promising field of research. The subsequent chapters provide insights on how nanotechnology-based therapeutics are moving towards revolutionizing cancer and infectious disease treatment by minimizing toxicity and facilitating targeted delivery of drugs.

理解癌症的分子机制是转变癌症治疗的关键。人类基因中相当比例的基因表现出替代剪切现象，并且在多种癌症中观察到前mRNA剪切的异常调控。本书进一步探讨了这些问题。开头几章介绍了基因组学在替代剪切研究中的作用以及这些机制在癌症发病机制中的靶标。纳米技术在癌症预防、检测和治疗领域的应用进展及其前景是一个很有希望的研究领域。接下来的内容则探讨了基于纳米技术的治疗方法如何朝着革命性地改变癌症和感染性疾病治疗的方向发展，通过减少毒性并促进药物的靶向递送来实现这一目标。

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