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RNA 病毒与神经系统疾病

English | 2023 | ISBN: 9781003285823 | 262 pages | True PDF | 22.99 MB

This volume is an accessible introduction to RNA viruses and the infectious outcomes that they cause in the central nervous system (CNS). Chapters cover the major RNA viruses, their impact on the CNS, and the similarities and differences in pathological outcomes that can be observed. Neuroscientists, be they students, researchers, or clinicians, will benefit from the timely coverage provided.

Our understanding of viruses, and specifically RNA viruses and their pathological impact, is rapidly evolving. For example, the close molecular interaction of viruses with the CNS cell types in the human host is poorly understood. Readers can use the book to understand clearly the cellular and molecular mechanisms governing pathological outcomes of RNA virus infection in the cell types of the human brain (e.g., neurons, endothelial cells, astrocytes, resident immune cells) based on summarized case studies, and gain insight into how cell type-specific defects affect brain function and cause poor clinical outcomes.

The book is aimed primarily at neuroscience students and postgraduates wishing to learn about virology and professionals who are interested to learn more about virus-associated neuropathology. A basic knowledge of cell and molecular biology is assumed; however, readers across the disciplines of science, technology, engineering, and mathematics will find this topical and timely publication of value.


这本著作是一本易于理解的RNA病毒及其在中枢神经系统(CNS)中引发感染后果的介绍。章节涵盖了主要的RNA病毒、它们对CNS的影响,以及病理学结果的不同相似之处和不同点。无论是学生、研究人员还是临床医生,神经科学家都会从该书提供的及时内容中受益。 我们对于病毒的理解,尤其是RNA病毒及其病理影响的认识正在迅速发展。例如,人类宿主中的病毒与CNS细胞类型之间的密切分子相互作用尚不为人所理解。读者可以利用本书基于总结的案例研究了解RNA病毒感染的人脑细胞(如神经元、内皮细胞、胶质细胞和驻留免疫细胞)引起的病理学后果背后的细胞和分子机制,并了解到特定于细胞类型的缺陷如何影响大脑功能并导致不良临床结果。 这本书主要针对希望了解病毒学以及对病毒相关神经系统疾病感兴趣的研究生和专业人士。假设读者具备基本的细胞和分子生物学知识;然而,所有来自科学、技术、工程和数学领域的学科读者都将发现该书的内容具有时效性和价值。
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