震颤障碍的机制与新兴疗法（第二版）

English | 2023 | ISBN: 3031261275 | 1045 Pages | PDF (True) | 14 MB

Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society. New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.

震颤与中枢神经系统和周围神经系统的众多相互作用紧密相连，这些相互作用调谐着运动控制。从大脑皮层到外周效应器。中央生成活动、反射回路延迟、惯性、刚性和阻尼都影响着震颤的特征。这次全面更新的新版探讨了震颤的发生机制，包括膜机制和啮齿动物模型，遗传学的进步以及与身体振动相关的肌肉骨骼模型。在这次临床实践中遇到的主要震颤形式进行了考虑，同时也考虑到了神经影像学方面。本书涵盖了评估方法和技术的最新进展，并提供了日常管理中实用的信息。这次更新版由国际帕金森病和运动障碍学会震颤工作组的指导原则所启发。新章节包括分类震颤、医源性震颤、静息态fMRI以及Gabaergic途径。除了药物治疗，神经外科方法如深部脑刺激（DBS）和杏仁核切除术也被讨论。介绍了一些正在开发中的新兴技术。

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