《单侧腹膜透析：理论、技术与临床实践》（PDF）

English | PDF | 2016 | 346 Pages | ISBN : 3319233319 | 7.7 MB

This book gives a complete description of online hemodiafiltration, in five sections. It is unique in the systematic and complete way in which hemodiafiltration is described. Each chapter is completed by a point-to-point summary of essential information, in a separate text box. Part of the book is dedicated to the theoretical background of convective clearance. In this part, safety issues and quality control is reviewed (especially on the quality of water for dialysis and substitution fluid), as well as equipment (both dialyzers and machines) with which this treatment can be performed. As recently the results of several randomized controlled trials were available, the effect of hemodiafiltration on hard clinical end points (mortality and morbidity) is discussed in detail. This has not been done before, as the most recent book/journal on hemodiafiltration was published in 2011, before the results of the 3 randomized controlled trials were published. Furthermore, the methodological quality of the trials is discussed by an expert, in order to help the readers in their judgment of the trials Part of the book concentrates on the effect of the treatment on several biomarkers and uremic toxins. Several clinically relevant issues is discussed separately, such as the prescription of anticoagulation during the treatment, drug prescription and clearance for patients treated with hemodiafiltration, and hemodynamic stability. Finally, a practical guide on how to perform the treatment is provided. In this unique section, seemingly simple but important details of hemodiafiltration-treatment is discussed, such as the importance of needle size for blood flow rates, the difference between filtration fraction and substitution ratio, the different targets that can be set and how to reach them. As most literature is mainly focused on theoretical issues, this unique feature really will help the field to perform hemodiafiltration, and answer practical questions.

这本书全面描述了在线血液透析滤过，分为五部分。它以独特的方式系统和详细地介绍了血液透析滤过。每章都附有一份关键信息的要点总结，放在独立的文本框中。书中的一部分专门讨论了对流清除的理论背景。这部分回顾了安全问题以及透析用水和置换液的质量控制（特别是设备质量），还包括可以进行这种治疗的设备（包括透析器和机器）。最近已有几项随机对照试验的结果可用，因此详细讨论了血液透析滤过对临床终点（死亡率和发病率）的影响。这是前所未有的，因为最近年出的关于血液透析滤过的书籍或期刊出版于2011年，在此之前还没有公布这三项随机对照试验的结果。此外，还由专家讨论了这些研究的方法学质量，以帮助读者判断这些研究。书中的一部分集中讨论了治疗对多个生物标记物和尿毒毒素的影响。对于与血液透析滤过治疗相关的临床相关问题进行了专门讨论，包括治疗期间抗凝剂的处方、患者接受血液透析滤过时药物处方及其清除情况以及血流动力学稳定性。最后提供了处理这种治疗的实际指南。在这一独特部分中，似乎简单但重要的血液透析治疗细节进行了讨论，例如血流量速率的重要性，过滤分数与置换比之间的区别，可以设定的不同目标及如何实现这些目标。由于大多数文献主要关注理论问题，因此这个独特的功能确实会帮助该领域执行血液透析滤过，并回答实际问题。

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