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Gasotransmitters: 生理学和病理生理学

English | PDF | 2012 | 209 Pages | ISBN : 3642303374 | 3.8 MB

Since the epochal discovery of the radical and highly toxic gas nitric oxide (NO) as a signaling molecule, two other no less toxic gases – carbon monoxide (CO) and hydrogen sulfide (H2S) – have been found to also be involved in a plethora of physiological and pathophysiological functions. The gases termed gasotransmitters play an increasingly important role in understanding how signalling into and between cells is modulated and fine-tuned. The advent of gasotransmitters has profoundly changed our way of thinking about biosynthesis, liberation, storage and action mechanisms in cellular signaling. In recent years an impressive amount of new data, distributed throughout the existing literature, has been generated. For this book the editors have recruited distinguished colleagues in the field to summarize and review important biological, pharmacological and medical functions and their implications, as well as methods for the detection of gasotransmitters.


自硝酸盐(NO)作为信号分子的 epochal 发现以来,两种同样有毒的气体——一氧化碳(CO)和硫化氢(H2S),也被发现参与了诸多生理及病理生理功能。被称为气体传递者(gasotransmitters)的这些气体在理解细胞间信号传导的调节与精调方面发挥着越来越重要的作用。气体传递者的出现深刻地改变了我们对生物合成、释放、存储和作用机制的认识。近年来,已有大量新的数据被生成,散布在现有的文献中。为了这本书,编辑们从该领域招募了著名的同事来总结并审查重要且有影响力的生物学、药理学及医学功能及其影响,以及检测气体传递者的方法。
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