脂质体药物 delivery: 系统原理与应用

English | 2023 | ISBN: 9781003459811 | 837 pages | True PDF | 30.9 MB

This book appraises the role of lipid-based drug delivery systems (LBDDSs) with respect to the bioavailability and controlled delivery of complex drug molecules for improving their clinical viability. It covers the latest developments and advancements in the field of drug delivery, and explores and compiles information on the current situation of lipid-based formulations used as versatile excipients and all their possible routes to improve therapeutic benefits. The book discusses novel formulations such as depot formulations, micro- and nanoemulsions, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), liposomes, nanoliposomes, micelles, nanosuspensions, lipid implants and inserts, and lipid nanotubes. It presents preparation methods of LBDDSs and their physicochemical properties, and portrays their various application angles and their impacts on drug-conveyance frameworks when employed in vitro and in vivo. The book is beneficial for researchers working on lipid-based drug formulations as well as biological and translational drug delivery. It is also a useful resource for course work of students of various academic degree programs such as pharmacy, health sciences, biotechnology, and microbiology; postgraduate and PhD students; and postdoctoral fellows researching on nanomedicine-based drug delivery systems.

这本书评估了脂质基药物递送系统（LBDDSs）在提高复杂药分子生物利用度和可控释放方面的角色，以改善其临床可行性。它涵盖了药物递送领域的最新发展与进步，并探讨并汇总了作为多功能赋形剂的脂质基制剂目前的使用情况，以及它们可能如何进一步提升治疗效益。本书讨论了诸如缓释剂型、微囊和纳米乳、固体脂质纳米粒（SLNs）、纳米结构脂质载体（NLCs）、脂质体、纳米脂质体、毫微球、纳米悬浮液、脂质植入物和插入物，以及脂质纳米管等新型剂型。它介绍了LBDDS的制备方法及其物理化学性质，并描绘了其在体内和体外应用的各种角度及其对药物传递框架的影响。这本书对从事脂质基药物制剂研究的研究人员有益，同时也对生物技术和转化药学领域的学生（如药学、健康科学、生物技术及微生物学等各类学位课程的学生）、硕士生和博士生以及正在纳米医学递送系统领域研究的博士后研究人员具有很大的参考价值。

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