潜伏病毒感染的疫苗

English | 143 pages | Bentham Science Publishers (January 23, 2018) | 1681081334 | PDF | 6.37 Mb

Many viruses are known to persist in their host’s cells in a latent state without exhibiting virulence or symptoms of infection, hence, giving rise to the term ‘latent infections’. Vaccines for Latent Viral Infections is a clear and concise monograph which features a review of some well-known viruses that are capable of establishing latent infections in humans. These include herpes simplex virus (HSV), cytomegalovirus (CMV), varicella zoster virus (VZV), Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV).The book also highlights common features of each of these viruses and demonstrates how they are able to evade the host’s immune response. This brief monograph finally proposes a much needed shift in the approach to designing vaccines that will prevent establishment of virus latency. Vaccines for Latent Viral Infections serves as a handy reference for researchers interested in the basic virology of viruses capable of latent infections, the immune responses to these infections and the development of vaccines to tackle these pathogens.

许多病毒能够在宿主细胞中处于潜伏状态，而不表现出致病性或感染症状，因此产生了“潜伏感染”的术语。《疫苗治疗潜伏病毒感染》是一本清晰且简洁的专著，它概述了一些人类可以建立潜伏感染的知名病毒。包括单纯疱疹病毒（HSV）、巨细胞病毒（CMV）、水痘-带状疱疹病毒（VZV）、Epstein-Barr病毒（EBV）和人类免疫缺陷病毒（HIV）。本书还突出了这些病毒的共同特征，并展示了它们如何能够逃避宿主的免疫反应。这本书最终提出了预防病毒潜伏感染设计疫苗的新方法。《疫苗治疗潜伏病毒感染》为研究具有潜伏性感染能力的病毒的基础病毒学、对该类感染的免疫应答以及开发应对这些病原体的疫苗提供了一个便捷的参考书。

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