Hodson and Geddes的《囊性纤维化》，第五版

English | 2023 | ISBN: 9781003262763 | 747 pages | True PDF | 60.73 MB

Cystic Fibrosis has seen dramatic advances in treatment since the last edition, including targeted cystic fibrosis transmembrane conductance regulator (CFTR) protein modulators for most CFTR gene abnormalities. This new fifth edition is an update and expansion of the rapid clinical and scientific advances in improving prognosis, and the impact of COVID-19, all of which has transformed conventional models of care. It covers basic science, such as how detailed understanding of the biology of the CFTR gene and protein has led to novel and beneficial therapies, as well as all aspects of clinical management in high-, middle- and low-income settings and the voices of individuals with CF from across the world. It will be a useful reference for clinicians, including all levels of trainees, across the whole multidisciplinary team, scientists and students.

Key Features • Follows an appealing organization of chapters, by developing fundamental knowledge of the reader before moving on to more complex or developing topics. • Presents a comprehensive, authoritative and up-to-date text, integrating fundamental science and clinical aspects of cystic fibrosis providing an attractive read for clinicians, trainee doctors and scientists. • Draws on global expertise and reflects best evidence-based practice from experts conducting cutting-edge clinical and basic science research from around the world.

囊性纤维化自上一版以来已经取得了显著的治疗进展，包括针对大多数CFTR基因异常的靶向囊性纤维化转运蛋白（CFTR）蛋白质调节剂。这一新的第五版是对改善预后和COVID-19的影响的快速临床和科学进步的更新与扩展，这些变化已经彻底改变了传统的护理模式。它涵盖了基本科学知识，例如如何对囊性纤维化基因及蛋白质的理解更加详细而引领了新型且有益的治疗方法，同时也涵盖了高、中、低收入国家在内的所有临床管理方面以及来自世界各地的囊性纤维化病人的声音。它将为医生、从初级培训者到高级训练者的整个多学科团队中的临床医生、科学家和学生提供有用的参考资料。 关键特点 • 按章节组织结构引人入胜，首先建立读者的基本知识，然后转向更复杂或发展中的主题。 • 提供全面、权威且最新的文本，结合了囊性纤维化的基础科学和临床方面，为临床医生、初级医生培训者和科学家提供有吸引力的读物。 • 取资全球资源，并反映来自世界各地在前沿临床和基本科学研究领域的专家的最佳基于证据实践。

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