新兴的契克拉病
The book focuses on a global problem challenging the health systems. Trypanosoma cruzi infections are transmitted by cone-nosed triatomine bugs, by blood transfusion and congenitally from mothers to their offspring. The American Trypanosomiasis affects 20 million people; among them a significant parcel (<1/3) will develop Chagas disease in the heart and digestive tract, where the immune system effector cells destroy target host cells. Genotype modifications resulting from transfer of minicircle sequence kDNA from the parasite into the host´s genome may explain the autoimmune pathogenesis of the disease. The book discusses various aspects of this disease and should be of interest to readers who wish to keep abreast of the developments in this field.
这本书专注于一个挑战全球健康系统的全球性问题。朱巴斯曼滴虫感染通过锥蝽传播、通过输血和从母亲传给后代而被传染。美洲锥虫病影响了2000万人;其中,有一半左右(约1/3)的人将在心脏和消化道中发展成克里萨达病,其中免疫系统的效应细胞破坏目标宿主细胞。来自寄生虫的微环序列kDNA从宿主基因组转移导致的基因型变化可能解释该疾病的自身免疫发病机制。本书讨论了这种疾病的各种方面,并应吸引希望了解这一领域发展的读者的兴趣。
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