液相色谱的数学建模与放大

English | PDF | 1995 | 139 Pages | ISBN : 3540588841 | 9.7 MB

Liquid chromatography has proved to be one of the most important tools for separations. Rapid development in biotechnology has increased the demand for chromatography in analytical, preparative and large scale applications. The understanding of the dynamics of chromatography is imperative for the scale-up. This book is a systematic treatment of the general rate models for various forms of liquid chromatography including adsorption, size exclusion, affinity, reversed phase, hydrophobic interaction, and radial flow chromatography. Thermodynamic and mass transfer effects in liquid chromatography are discussed. Applications of computer programs for the rate models are described and the procedures for the scale-up of preparative- and large-scale liquid chromatography using the general rate models are given.

液相色谱已被证明是分离技术中最重要的一种工具。生物技术的快速发展增加了分析、制备和大规模应用中对色谱的需求。理解色谱的动力学对于扩大规模至关重要。本书系统地讨论了各种形式的液相色谱（包括吸附、大小排阻、亲和、反相、疏水相互作用和径向流动色谱）的一般速率模型，还讨论了液体色谱中的热力学及质量传递效应。描述了计算机程序在速率模型应用方面的内容，并给出了利用一般速率模型进行制备性和大规模液相色谱扩大的具体步骤。

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