β-Carbolines: A Privileged Scaffold for Modern Drug Discovery

English | 2025 | ISBN: 1138482382 | 283 pages | True PDF EPUB | 61.52 MB

β-Carbolines: A Privileged Scaffold for Modern Drug Discovery provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carboline scaffold and their biological evaluation.

β-carboline and its derivatives have generated considerable interest in recent years for their versatile properties in chemistry and pharmacology. This is due to their ability to act as agonists to benzodiazepine receptors, hydroxy serotonin receptors, and intercalate into DNA and to inhibit CDK, topisomerase, and monoamine oxidase enzymes. Their pharmacological properties include anxiolytic, hypnotic, anticonvulsant, antiviral, antiparasitic, and antimicrobial attributes. This book provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carboline scaffold and their biological evaluation.

Features

Focuses on the different application and therapies of β-carbolines. Provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carbolines. Discusses methods of biological evaluation of β-carbolines. Explores different chemical transformations occurring with synthesis using β-carbolines. Covers both heterocyclic synthesis and multicomponent synthesis related to β-carboline.

This text is key reading for researchers in medicinal chemistry and drug discovery looking to understand the broad potential of β-carbolines.

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